Do not take Atovaquone/Proguanil Hydrochloride

 if you are allergic to atovaquone, proguanil hydrochloride or any of the other ingredients of thismedicine (listed in section 6).

 for preventing malaria, if you have severe kidney disease.

Tell your doctor if either of these applies to you.

Warnings and precautions

Talk to your doctor or pharmacist before taking Atovaquone/Proguanil Hydrochloride.

Children

Atovaquone/Proguanil Hydrochloride 250 mg/100 mg film-coated tablet is not recommended in childrenwho weigh less than 11 kg. Another strength of atovaquone/proguanil tablet may be available which aremore suitable for children who weigh less than 11 kg.

Other medicines and Atovaquone/Proguanil Hydrochloride

Tell your doctor or pharmacist if you are taking or have recently taken or might take any other medicines.Some medicines can affect the way Atovaquone/Proguanil Hydrochloride works, or Atovaquone/ProguanilHydrochloride itself can strengthen or weaken the effectiveness of other medicines taken at the same time.These include:

metoclopramide, used to treat nausea and vomiting

the antibiotics, tetracycline, rifampicin and rifabutin

favirenz or certain highly active protease-inhibitors used to treat HIV

warfarin and other medicines that stop blood clotting

etoposide used to treat cancer

Tell your doctor if you are taking any of these. Your doctor may decide that Atovaquone/ProguanilHydrochloride is not suitable for you, or that you need extra check-ups while you are taking it.

Remember to tell your doctor if you start taking any other medicines while you are takingAtovaquone/Proguanil Hydrochloride.